Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors
نویسندگان
چکیده
منابع مشابه
Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors.
OBJECTIVE Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (Cx36KO) mice using a pentylenetetrazol (PTZ) model. METHODS Mice (2-3months old) with Cx36 wildtype (WT) or Cx36KO genotype were t...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2010
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2010.09.006